Definition - What does Actos mean?

Actos is the brand name for a drug called Pioglitazone, which is manufactured by the Japanese pharmaceutical company Takeda Pharmaceuticals. As of 2015, it is the most popular Type 2 Diabetes medication sold in the United States.

Actos is an oral prescription medication used by Type 2 diabetics to control their blood sugar levels. It is generally used in conjunction with other anti-diabetic medications, including metformin or glyburide.

In 2011, the United States Food and Drug Administration (FDA) published a warning informing the public that the “use of the diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer.” Following the warning, users filed lawsuits against Takeda Pharmaceutical alleging that Takeda failed in their duty to adequately warn patients of the increased risk of bladder cancer resulting from the use of Actos.

Justipedia explains Actos

In April 2014, a jury awarded an Actos patient $9 billion, the largest award of its kind at that time. Legal experts estimate the manufacturer could face more than 10,000 additional lawsuits within the U.S. with other users claiming that Takeda knew of the risks of the medication and its links to bladder cancer but refused to stop the sale of the drug. Actos has been banned in France and Germany.

It is estimated that as many as 27 million individuals in the United States may have Type 2 diabetes. Type 2 diabetes is a chronic health condition where an individual’s body does not properly metabolize sugar (glucose). As a result, sugar levels in the body can rise too high.

Actos has two functions: it can reduce the amount of glucose the liver produces, or it can increase the rate the liver, muscle cells, and fat respond to insulin. Actos, if used properly and successfully, can reduce the risk that Type 2 diabetics will suffer kidney and nerve damage, blindness, stroke, or heart attack.

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